IFC Comments on Recent Mathematical Modeling study of BPA Toxicokinetics by Edginton and Ritter
Edington and Ritter present a mathematical model of the toxicokinetics of BPA and its glucuronidated metabolite, BPA-Glu, and estimate that the average steady state BPA plasma concentration in newborns is eleven times that in adults, when given the same weight-normalized dose.1 Additionally, they estimate by simulating typical feeding exposures, infants 3 and 6 months old show a five times greater steady state BPA plasma concentration when compared to adults.